Contribuição ao conhecimento químico de plantas do Nordeste: Cissus verticillata L. (Vitaceae)

Abstract

The presente work describe the results of chemical study of Cissus verticillata (Vitaceae), plant known as insulin and commonly used as anti-diabetic. Using column chromatography on silica gel from the hexane extract of the stems was isolated a steroid (β-sitosterol), while the hexane extract of leaves provided an alcohol (tetracosonol) and a pentaciclic triterpene (3β-taraxerol). In addition, from the original constituents, using classical chemical reactions (acetylation, oxidation and formulation), derivatives were prepared in order to compare the original constituents with the derivatives with respect to anticholinesterase activity. We also studied the composition of fatty acids present in the hexane extract of the stems through the process of saponification followed by methylation and analised using gas chromatography coupled to mass spectrometry. All compounds original constituents and derivatives) were characterized by spectrometric methods, nuclear magnetic resonance (NMR) 1H and 13C, infra-red and mass spectroscopic.