Fatores de risco associados à transmissão da sífilis congênita : uma revisão sistemática

Abstract

Syphilis is an infectious disease caused by the bacterium Treponema Pallidum, which can be transmitted vertically (congenital syphilis) through the placenta from the mother to the fetus, which can result in miscarriages, late fetal losses, neonatal deaths, sick or asymptomatic neonates. may develop with severe complications if untreated. Despite having a well-definedetiologic agent, known forms of transmission, low cost treatment, easy access and excellent cure rates, syphilis presents itself as a public health problem. Objective: To carry out a systematic review of the publications on the risk factors related to the transmission of congenital syphilis. Materials and methods: This is a Systematic Review of scientific production literature with a qualitative approach, guided by the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-analyzes. The systematic review is recorded in the international database of the International Prospective Register of Systematic Reviews (PROSPERO) under the numbering CRD 42018090859. The population of the study was constituted by scientific productions on congenital syphilis, where the interest is to identify which factors of risks are associated to the vertical transmission of syphilis through the guiding question using the PICOS strategy used in the electronic databases: Embase, Medline, Lilacs and Web of Science. We considered all the scientific publications available in full in the years 2009 to 2019, in English, Portuguese and Spanish, without restriction as to the type of study, to address the risk factors associated with the transmission of congenital syphilis. The studies were selected by two independent reviewers to identify studies that meet the inclusion criteria, without the need for the third reviewer. A standardized record was used to collect associated variables such as: type of study, sample size, geographic location of the study, incidence of syphilis and associated risk factors. For the classification of the level of evidence and degree of recommendation will be used the Oxford Center for Evidence Based Medicine, in adapted version. Products: The products of this dissertation contemplate an original article and an Executive Summary destined to the manager of the Municipal Health Department of the city of Fortaleza-CE as subsidy to the decision making.