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Title in Portuguese: Topical anti-inflammatory potential of Physalin E from Physalis angulata on experimental dermatitis in mice
Author: Pinto, Natália Bitú
Morais, Talita Cavalcante
Carvalho, Karine Maria Martins Bezerra
Silva, Cecília Rocha
Andrade, Geanne Matos de
Brito, Gerly Anne de Castro
Veras, Maria Leopoldina
Pessoa, Otília Deusdênia Loiola
Rao, Vietla Satyanarayana
Santos, Flávia Almeida
Keywords: Antígeno Polipeptídico Tecidual
Issue Date: Aug-2010
Publisher: Phytomedicine
Citation: PINTO, N.B. et al. Topical anti-inflammatory potential of Physalin E from Physalis angulata on experimental dermatitis in mice. Phytomedicine, Jena, v. 17, n. 10, p. 740-743, ago. 2010.
Abstract: The anti-inflammatory effect of physalin E, a seco-steroid isolated from Physalis angulata L. was evaluated on acute and chronic models of dermatitis induced by 12-O-tetradecanoyl-phorbol-13- acetate (TPA) and oxazolone, respectively, in mouse ear. The changes in ear edema/thickness, production of pro-inflammatory cytokines (TNF- a and IFN- g ), myeloperoxidase (MPO) activity, and histological and immunohistochemical findings were analysed, as indicators of dermal inflammation. Similar to dexamethasone, topically applied Physalin E (0.125; 0.25 and 0.5 mg/ear) potently inhibited the TPA and oxazolone-induced dermatitis, leading to substantial reductions in ear edema/thickness, pro-inflammatory cytokines, and MPO activity. These effects were reversed by mifepristone, a steroid antagonist and confirmed by immunohistochemical and histopathological analysis. The data suggest that physalin E may be a potent and topically effective anti-inflammatory agent useful to treat the acute and chronic skin inflammatory conditions.
metadata.dc.type: Artigo de Periódico
ISSN: 0944-7113
Appears in Collections:DMC - Artigos publicados em revistas científicas

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