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dc.contributor.authorPinto, Natália Bitú-
dc.contributor.authorMorais, Talita Cavalcante-
dc.contributor.authorCarvalho, Karine Maria Martins Bezerra-
dc.contributor.authorSilva, Cecília Rocha-
dc.contributor.authorAndrade, Geanne Matos de-
dc.contributor.authorBrito, Gerly Anne de Castro-
dc.contributor.authorVeras, Maria Leopoldina-
dc.contributor.authorPessoa, Otília Deusdênia Loiola-
dc.contributor.authorRao, Vietla Satyanarayana-
dc.contributor.authorSantos, Flávia Almeida-
dc.identifier.citationPINTO, N.B. et al. Topical anti-inflammatory potential of Physalin E from Physalis angulata on experimental dermatitis in mice. Phytomedicine, Jena, v. 17, n. 10, p. 740-743, ago. 2010.pt_BR
dc.description.abstractThe anti-inflammatory effect of physalin E, a seco-steroid isolated from Physalis angulata L. was evaluated on acute and chronic models of dermatitis induced by 12-O-tetradecanoyl-phorbol-13- acetate (TPA) and oxazolone, respectively, in mouse ear. The changes in ear edema/thickness, production of pro-inflammatory cytokines (TNF- a and IFN- g ), myeloperoxidase (MPO) activity, and histological and immunohistochemical findings were analysed, as indicators of dermal inflammation. Similar to dexamethasone, topically applied Physalin E (0.125; 0.25 and 0.5 mg/ear) potently inhibited the TPA and oxazolone-induced dermatitis, leading to substantial reductions in ear edema/thickness, pro-inflammatory cytokines, and MPO activity. These effects were reversed by mifepristone, a steroid antagonist and confirmed by immunohistochemical and histopathological analysis. The data suggest that physalin E may be a potent and topically effective anti-inflammatory agent useful to treat the acute and chronic skin inflammatory conditions.pt_BR
dc.subjectAntígeno Polipeptídico Tecidualpt_BR
dc.titleTopical anti-inflammatory potential of Physalin E from Physalis angulata on experimental dermatitis in micept_BR
dc.typeArtigo de Periódicopt_BR
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