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http://repositorio.ufc.br/handle/riufc/5278| Tipo: | Artigo de Periódico |
| Título: | In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii |
| Autor(es): | Cordeiro, Rossana de Aguiar Brilhante, Raimunda Sâmia Nogueira Rocha, Marcos Fábio Gadelha Medrano, Delia Jessica Astete Monteiro, André Jalles Tavares, Juliane Lira Lima, Rita Amanda Chaves de Camargo, Zoilo Pires de Sidrim, José Júlio Costa |
| Palavras-chave: | Antifúngicos;Antituberculosos |
| Data do documento: | Set-2009 |
| Instituição/Editor/Publicador: | International Journal of Antimicrobial Agents |
| Citação: | CORDEIRO, R. A. et al. In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii. International Journal of Antimicrobial Agents, v. 34, n. 3, p. 278-280, set. 2009. |
| Resumo: | The aim of the present study was to evaluate the in vitro interactions of antituberculous drugs (ATDs) withantifungalsagainst Coccidioidesposadasii .Eighteendrugcombinations,formedbyanATD(isoniazid, pyrazinamideorethambutol)plusanantifungal(amphotericinB,ketoconazole,itraconazole,fluconazole, voriconazole or caspofungin), were tested using the checkerboard method. All the antimicrobial combi- nations inhibited C. posadasii strains and synergistic interactions were observed for 10 combinations. Antagonism between the tested drugs was not observed. Stronger synergistic interactions were seen in thecombinationsformedbytriazolesplusethambutolaswellasitraconazolepluspyrazinamide.Further studies in animal models are needed to confirm the usefulness of these combinations |
| URI: | http://www.repositorio.ufc.br/handle/riufc/5278 |
| ISSN: | 0924-8579 |
| Aparece nas coleções: | DMC - Artigos publicados em revistas científicas |
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| Arquivo | Descrição | Tamanho | Formato | |
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| 2009_art_raclima.pdf | 116,02 kB | Adobe PDF | Visualizar/Abrir |
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