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Title in Portuguese: In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii
Author: Cordeiro, Rossana de Aguiar
Brilhante, Raimunda Sâmia Nogueira
Rocha, Marcos Fábio Gadelha
Medrano, Delia Jessica Astete
Monteiro, André Jalles
Tavares, Juliane Lira
Lima, Rita Amanda Chaves de
Camargo, Zoilo Pires de
Sidrim, José Júlio Costa
Keywords: Antifúngicos
Issue Date: Sep-2009
Publisher: International Journal of Antimicrobial Agents
Citation: CORDEIRO, R. A. et al. In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii. International Journal of Antimicrobial Agents, v. 34, n. 3, p. 278-280, set. 2009.
Abstract in Portuguese: The aim of the present study was to evaluate the in vitro interactions of antituberculous drugs (ATDs) withantifungalsagainst Coccidioidesposadasii .Eighteendrugcombinations,formedbyanATD(isoniazid, pyrazinamideorethambutol)plusanantifungal(amphotericinB,ketoconazole,itraconazole,fluconazole, voriconazole or caspofungin), were tested using the checkerboard method. All the antimicrobial combi- nations inhibited C. posadasii strains and synergistic interactions were observed for 10 combinations. Antagonism between the tested drugs was not observed. Stronger synergistic interactions were seen in thecombinationsformedbytriazolesplusethambutolaswellasitraconazolepluspyrazinamide.Further studies in animal models are needed to confirm the usefulness of these combinations
metadata.dc.type: Artigo de Periódico
ISSN: 0924-8579
Appears in Collections:DMC - Artigos publicados em revistas científicas

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