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Title in Portuguese: Sesquiterpene farnesol contributes to Increased susceptibility to beta-Lactams in strains of burkholderia pseudomallei
Author: Brilhante, Raimunda Sâmia Nogueira
Valente, L. G. A.
Rocha, Marcos Fábio Gadelha
Bandeira, Tereza de Jesus Pinheiro Gomes
Cordeiro, Rossana de Aguiar
Lima, Rita Amanda Chaves de
Leite, João Jaime Giffoni
Ribeiro, Joyce Fonteles
Castelo-Branco, Débora de Souza Collares Maia
Monteiro, Andre Jalles
Sidrim, José Júlio Costa
Pereira, J. F.
Keywords: beta-Lactamas
Issue Date: Apr-2012
Publisher: Antimicrobial Agents and Chemotherapy
Citation: BRILHANTE, R. S. N. et al. Sesquiterpene farnesol contributes to increased susceptibility to beta-Lactams in strains of Burkholderia pseudomallei. Antimicrobial Agents and Chemotherapy, v. 56, n. 4, p. 2198-2200, abr. 2012.
Abstract: This study aimed to evaluate the in vitro combination of farnesol and -lactams against Burkholderia pseudomallei . A total of 12 -lactamase-positive strains were tested according to CLSI standards. All strains were inhibited by farnesol, with MICs ranging from 75 to 150 M. The combination of this compound with -lactams resulted in statistically significant -lactam MIC reduc- tion ( P < 0.05). This study provides new perspectives for the use of farnesol combined with -lactam antibiotics against strains of B. pseudomallei.
metadata.dc.type: Artigo de Periódico
ISSN: 0066-4804
Appears in Collections:DMC - Artigos publicados em revistas científicas

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