Desenvolvimento e caracterização de membranas de amido e amido com sulfato de condroitina

Abstract

There is an increase of consumers for natural products with functional appeal. Due to low cost and excellent biodegradability, the use of starch as a raw material for films production is growing in interest. However, the properties of starch-based materials are affected by relative humidity during their use and storage due to their hydrophilic character. This work aims at the production and characterization of membranes or films with starch and starch with SC. Films were produced by casting with starch (4g and 5g/100g filmogenic solution), chondroitin sulfate (10, 15 and 20g/100g polymer) and sorbitol (20g and 50g/100g of polymer) as plasticizer. Natural chondroitin sulfate was incorporated in filmogenic solution at different rates to obtain films. The films were macroscopically characterized and swelling index and disintegrating test were determined. Results indicated changed transparency, disintegration time and swelling degree, coupled to their dependence on increase in chondroitin sulfate concentration. Increased in SC concentration reduced the hydrophilic character of starch. The plasticizer effect of sorbitol could be demonstrated by the increase in flexibility of the films. Films composed of polymeric association showed hydration levels, desintegration and morphological properties which allow them to be applied as excipients in the development of new drug delivery systems.