Tratamento com gel fitoterápico à base de Myracrodruon urundeuva na cicatrização de úlceras orais por Cisplastina in vitro

Abstract

The Brazilian pepper tree (Myracrodruon urundeuva Allemão - Mu), Anacardiaceae, is a species from northeastern Brazil widely used in traditional medicine due to its property’s therapeutics recognized, as actions anti-inflammatory, antimicrobial and healing. These properties are mainly attributed to the presence of polyphenolic compounds such as tannins and chalcones dimeric. Despite of your use to be infused in the culture, studies that evaluate the toxicity of plant-derived formulations and their nociceptive and anti-inflammatory capacity, especially in orofacial models in vivo, do not yet present information considered in the literature. In this context, the present work has the general objective of evaluating the dental phytotherapeutic gel the base of Myracrodruon urundeuva German in oral mucositis, which is presented in four chapters: Chapter 1: Traditional uses, phytochemical studies and activities biological of Myracrodruon urundeuva (aroeira-do-sertão): a narrative review. This is an article with your methodology extensive on Mu, where it was realized that this is a remarkable plant of ethnopharmacological, technical-scientific and socioeconomic values; Chapter 2: From traditions to innovations: the pharmacochemical potential of aroeira-do-sertão (Myracrodroun) urundeuva German . It is an article that addresses Mu's technological and sustainable innovations, where the patent search took place between August and September 2024, with no time restrictions on the date of application or publication , thus allowing mapping the panorama of development technological related to this plant; Chapter 3: Preclinical evaluation of activity toxicological and nociceptive of gel of Myracrodruon urundeuva German for dental purposes in zebrafish ( danio rerio ) adult. Initially, preliminary pharmacognostic studies were carried out with the inner bark and gel preparation at 10% and 20%. Animal experiments were then performed using zebrafish to test toxicity and orofacial pain; the results demonstrated a satisfactory safety profile in zebrafish mucosa, causing no toxicity and demonstrating significant signs of nociceptive action, suggesting it could have analgesic properties. thus proving what the gel and effective in controlling nociception ; Chapter 4: Analysis of the efficacy and efficiency of Myracrodruon -based herbal gel urundeuva Allemão in the healing of oral ulcers in experiments with rats Wister , where it was observed that the 10% phytotherapeutic gel is effective in oral treatments, with healing potential, possible analgesic and antiulcer effect , in line with the trials with zebrafish, demonstrating promising results with predictability of its safety in oral mucositis.