Avaliação do teor de Aciclovir para administração em sondas de nutrição enteral

Abstract

The administration of medications via enteral feeding tubes (EFT) in hospitalized or home care patients presents challenges that require careful analysis of factors such as the characteristics of the drug, the type of feeding tube used, and potential interactions. Acyclovir was chosen for this study due to its widespread use in the treatment of viral infections in debilitated patients, including those who depend on enteral feeding, making it essential to ensure the efficacy of its administration through feeding tubes. This study evaluated the stability and safety of acyclovir administration via EFTs made of different materials (polyvinyl chloride - PVC, polyurethane - PU, and silicone) to determine the impact of tube material on drug recovery. The study was conducted in vitro, with the acyclovir content measured using UV spectrophotometry, employing a validated method with parameters of selectivity, linearity, precision, and accuracy. For the analysis, acyclovir tablets were disintegrated and dissolved, then passed through the tubes, and the remaining drug content was quantified to assess drug sorption. Additionally, the dosing method was compared with the method described by the Brazilian pharmacopoeia. The method's selectivity was confirmed by the absence of interference from excipients, and linearity was established in the range of 6 to 16 μg/mL, with a correlation coefficient of R² = 0.9989. Precision showed a Relative Standard Deviation (RSD) below 5%, and accuracy showed a mean recovery of 100.13%. The weight of the acyclovir tablets was also determined to ensure uniform dosing, the médium weight was 519,14 mg and the medium dosagem was 98,71 %. In the dosage results after administration, the mean concentrations of acyclovir recovered after passing through the tubes were 101,56% (PVC), 98,31% (PU), and 99,17% (silicone), with no statistically significant difference between the tube materials in relation to drug sorption. These results indicate that drug loss was minimal, confirming the viability of the tested materials for acyclovir administration via EFT. The study concludes that acyclovir administration via enteral feeding tubes is safe and effective in the materials tested.