Estudo da correlação entre velocidade de onda de pulso, índices inflamatórios sistêmicos e doença coronária assintomática: um link para indicação de tratamento clínico vs. cirúrgico (implante de stent)

Abstract

Cardiovascular disease (CVD) is the leading cause of mortality worldwide,accounting for approximately one-third of all deaths. Acute Myocardial Infarction (AMI)may be the first manifestation of CVD, leading to sudden death or irreversible muscledamage. Establishing low-cost biomarkers such as Pulse Wave Velocity (PWV) andSystemic Immunoinflammatory Indices (SII) as related to the need for complex examsis essential to prevent AMI and initiate early treatment. This study evaluated 190 patients diagnosed with asymptomatic coronary disease,analyzing risk factors, pulse wave velocity, and peripheral blood neutrophil/lymphocyteand platelet/lymphocyte ratios. The results indicated that diabetic, male, and smokingpatients, as well as those with elevated inflammatory indices and pulse wave velocity,showed a greater need for interventional treatment with stent implantation (p<0.05). In the conclusion, it was observed that the relationships between blood cells(neutrophils, platelets, and lymphocytes), associated with arterial stiffness, can identifypatients with severe asymptomatic coronary disease who require invasivehemodynamic studies.