Construção e validação de protocolo de nutrição no transplante de células tronco hematopoieticas: terapia nutricional enteral precoce

Abstract

This study aims to develop and validate a nutritional protocol, seeking to systematize early enteral nutritional therapy for patients in the Bone Marrow Transplant Service (BMT) located at the Walter Cantídio University Hospital (HUWC). This is a methodological study, in which the development of the protocol was divided into two phases. The first phase involves the collection of scientific evidence through an integrative literature review, which was carried out in the PubMed and Lilacs databases. After cross-referencing the descriptors in English and Portuguese, and following the inclusion and exclusion criteria, 27 articles were eligible for the development of the protocol. The second phase consisted of validating the content through analysis by a committee of experts who were selected with experience and qualifications in the area of clinical nutrition, oncohematology, oncology and/or enteral nutrition therapy. The protocol was evaluated using a Likert scale ranging from 1 to 4, with the following being considered: 1 - disagree and 4 - totally agree. The theoretical analysis of the protocol was performed and submitted to the evaluation of 11 experts. Furthermore, in order to measure the proportion of evaluators in agreement with each aspect of the protocol, the Content Validity Index (CVI) was used, the acceptable level of agreement for validation being ≥80%. Then, the experts' suggestions were carefully analyzed and the changes were applied. Therefore, it was concluded that it was possible to construct and validate the protocol, since a CVI of 0.87 was obtained, demonstrating that its implementation is effective and well accepted for use in hospital practice.