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dc.contributor.authorSousa, Thiciana da S.-
dc.contributor.authorJimenez, Paula C.-
dc.contributor.authorFerreira, Elthon G.-
dc.contributor.authorSilveira, Edilberto R.-
dc.contributor.authorBraz-Filho, Raimundo-
dc.contributor.authorPessoa, Otília D. L.-
dc.contributor.authorCosta-Lotufo, Letícia Veras-
dc.date.accessioned2023-03-21T16:29:35Z-
dc.date.available2023-03-21T16:29:35Z-
dc.date.issued2012-
dc.identifier.citationSOUSA, Thiciana da S.; JIMENEZ, Paula C.;FERREIRA, Elthon G.; SILVEIRA, Edilberto R.; BRAZ FILHO, Raimundo; PESSOA, Otília D. L; COSTA-LOTUFO, Letícia Veras. Anthracyclinones from Micromonospora sp. Journal of Natural Products,United States, v. 75, p. 489-493, 2012. . Disponível em: https://pubs.acs.org/doi/pdf/10.1021/np200795p. Acesso em: 21 mar. 2023.pt_BR
dc.identifier.issn1539-8854-
dc.identifier.urihttp://www.repositorio.ufc.br/handle/riufc/71367-
dc.description.abstractFour new anthracyclinones, 4,6,11-trihydroxy9-propyltetracene-5,12-dione (1), 1-methoxy-9-propyltetracene-6,11-dione (2), 7,8,9,10-tetrahydro-9-hydroxy-1-methoxy9-propyltetracene-6,11-dione (3), and 10β-carbomethoxy-7, 8,9,10-tetrahydro-4,6,7α,9α,11-pentahydroxy-9-propyltetracene-5,12-dione (4), were isolated from a strain of Micromonospora sp. associated with the tunicate Eudistoma vannamei. All structures were established by 1D and 2D NMR (COSY, HSQC, HMBC, NOESY) and HRESIMS experiments. Compounds 1 and 4 were cytotoxic against the HCT-8 human colon adenocarcinoma cell line, with IC50 values of 12.7 and 6.2 μM, respectively, while compounds 2 and 3 were inactive.pt_BR
dc.language.isoenpt_BR
dc.publisherJournal of Natural Productspt_BR
dc.subjectAnthracyclinonespt_BR
dc.subjectChemical compoundspt_BR
dc.subjectCitotoxitypt_BR
dc.subjectAntracilinaspt_BR
dc.subjectCompostos químicospt_BR
dc.subjectCito-toxicidadept_BR
dc.titleAnthracyclinones from Micromonospora sp.pt_BR
dc.typeArtigo de Periódicopt_BR
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