Efeitos da solifenacina sobre comportamentos relacionados ao déficit cognitivo em camundongos fêmeas

Abstract

Current research has shown that the use of anticholinergic drugs, especially antimuscarinic drugs in a chronic form, has presented a risk of dementia and cognitive deficit, not only in elderly patients who use this drug the most, but also in young patients. Solifenacin is one of these drugs commonly used for the treatment of overactive bladder, classified as a voiding urgency. Given the above, the present research evaluated behavioral changes similar to cognitive loss in mice. The aim of the experiments was to determine the effects of solifenacin on behavioral changes related to short-term memory in the Central Nervous System (CNS). For carrying out the experiments, Swiss female mice were treated daily with solifenacin (1 or 2 mg/kg, by gavage) for 14 or 28 days. The behavioral tests used were the open field tests (locomotive activity, rearing, grooming) and object recognition. The results showed that the open field and rearing tests had no changes in relation to the control group. For the grooming test, there was a reduction in self-cleaning activity in animals that received Solifenacin at the highest dose (2 mg/kg) and for 28 days. In the recognition test, only the administration of solifenacin (2 mg/kg) per day for 28 days decreased the index of recognition of the new object in relation to the control group. Thus, it was possible to demonstrate that the administration of solifenacin for a longer period evaluated (28 days) had effects on short-term memory.