In vivo topical anti-inflammatory and wound healing activities of the fixed oil ofCaryocar coriaceum Wittm. seeds

Abstract

Ethnopharmacological relevance: Caryocar coriaceumWittm. (Caryocaraceae), popularly known as pequi,is important source of food and used in the folk medicine as wound healing, anti-inflammatory and forthe treatment of diseases of the respiratory tract, rheumatic and muscular pains and gastric ulcer.Aim of the study:To evaluate the effects of fixed oil ofCaryocar coriaceum(FOCC) on the topical inflam-mation and cutaneous wound healing.Materials and methods:FOCC was purchased commercially and used at 6%, 12%, 25%, 50% and 100% onmodel of ear edema induced by xylene and ointments formulations at 6% and 12% on wound excisionmodel in mice. Skin lesions were evaluated by planimetry and histological analysis.Results:FOCC was capable of reducing inflammation in a dose-dependent fashion. FOCC in nature (100%)inhibited the ear edema in 38.01% and 39.20% at time 15min and 1h, respectively, after induction ofinflammation, when compared to the positive control. The topical administration of FOCC ointment 12%showed a significantly reduction of unhealed wound area, with increased percentage of wound con-traction (96.54%) on day 7 when compared to the other groups. The results of histological evaluationsupported the outcome of excision wound model