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dc.contributor.authorCordeiro, Rossana de Aguiar-
dc.contributor.authorBrilhante, Raimunda Sâmia Nogueira-
dc.contributor.authorRocha, Marcos Fábio Gadelha-
dc.contributor.authorMedrano, Delia Jessica Astete-
dc.contributor.authorMonteiro, André Jalles-
dc.contributor.authorTavares, Juliane Lira-
dc.contributor.authorLima, Rita Amanda Chaves de-
dc.contributor.authorCamargo, Zoilo Pires de-
dc.contributor.authorSidrim, José Júlio Costa-
dc.date.accessioned2013-07-08T13:39:38Z-
dc.date.available2013-07-08T13:39:38Z-
dc.date.issued2009-09-
dc.identifier.citationCORDEIRO, R. A. et al. In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii. International Journal of Antimicrobial Agents, v. 34, n. 3, p. 278-280, set. 2009.pt_BR
dc.identifier.issn0924-8579-
dc.identifier.urihttp://www.repositorio.ufc.br/handle/riufc/5278-
dc.language.isoenpt_BR
dc.publisherInternational Journal of Antimicrobial Agentspt_BR
dc.subjectAntifúngicospt_BR
dc.subjectAntituberculosospt_BR
dc.titleIn vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasiipt_BR
dc.typeArtigo de Periódicopt_BR
dc.description.abstract-ptbrThe aim of the present study was to evaluate the in vitro interactions of antituberculous drugs (ATDs) withantifungalsagainst Coccidioidesposadasii .Eighteendrugcombinations,formedbyanATD(isoniazid, pyrazinamideorethambutol)plusanantifungal(amphotericinB,ketoconazole,itraconazole,fluconazole, voriconazole or caspofungin), were tested using the checkerboard method. All the antimicrobial combi- nations inhibited C. posadasii strains and synergistic interactions were observed for 10 combinations. Antagonism between the tested drugs was not observed. Stronger synergistic interactions were seen in thecombinationsformedbytriazolesplusethambutolaswellasitraconazolepluspyrazinamide.Further studies in animal models are needed to confirm the usefulness of these combinationspt_BR
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