Esteato-hepatite não alcoólica: uma síndrome em evidência

Abstract

This article presents a narrative review covering epidemiology, physiopathology, diagnosis and treatment of non-alcoholic steatohepatitis (NASH). During the last decades, there has been a growth on the global incidence of obesity and related diseases. Among them, NASH is highlighted as a metabolic disease with varied clinical presentation, part of the spectrum of the non-alcoholic fatty liver disease (NAFLD). In some studies, NAFLD has almost 25% prevalence on select populations, being more prevalent on male and hispanic subjects. The pathogenesis of the disease is highly complex and multifactorial, mostly based on obesity, insulin resistance and genetic heritage. After diagnosis, management mostly consists of lifestyle changes, treating metabolic syndrome, use of drugs, and treatment for hepatic cirrhosis. In face of the growing of its prevalence, it is of great medical interest to seek better early detection, treatment and complication control for this disease. These complex topics demand a multidisciplinary approach.