Nefrite intersticial induzida por mesalazina em gêmeos monozigóticos portadores de doença inflamatória intestinal : relato de caso

Abstract

Inflammatory bowel disease (IBD) has uncertain etiology, but environmental, genetic and immunological factors may together justify the pathogenesis, clinical and prognosis of these patients. The clinical manifestation is diverse, with renal involvement being one of the most prevalent. In addition, the genetic role for IBD has already been shown in several studies, especially in monozygotic siblings. The induction and maintenance of the treatment of mild / moderate cases of patients in clinical remission shows good efficacy with the use of 5-aminosalicylic acid (mesalazine). This medication, although rare, may also have renal involvement with interstitial nephritis being one of the main etiologies. Next, we describe the case of monozygotic IBD siblings who developed interstitial nephritis during treatment with mesalazine.