Efeito da mepivacaína 2% nos parâmetros cardiovasculares em cirurgias de terceiros molares

Abstract

When injected into the tissues, Local Anesthetics and Vasoconstrictors (VC) initiate the process of absorption and elimination, passing through the bloodstream to reach toxic levels or induce cardiovascular changes. The aim of this study was to evaluate the behavior of cardiovascular activity in the surgeries for the removal of third molars using mepivacaine 2% with adrenaline at a concentration of 1: 100,000 in a period of up to 120 min after the anesthetic injection. It is a longitudinal, interventional study with a quantitative and descriptive character, with measurable data for analysis and interpretation, carried out with patients of the discipline of surgical clinic of the dentistry course of the UniCatólica. The results obtained were analyzed using the normality test of Kolmogorov-Smirnov and compared during the trans-operative period by ANOVA for repeated measurements followed by the Bonferroni or Friedman post-test followed by the Dunn post-test adopting a 5% level of significance (p <0.05). The procedure with the anesthetic used did not cause changes in systolic blood pressure (SBP) (p = 0.712), diastolic blood pressure (DBP) (p = 0.098) as well as SBP and DBP difference (p = 0.546). In heart rate (HR) there was a significant difference in the time of 10 min (p = 0.013) and 120 min (p = 0.013). In the O2 Peripheral Saturation (SPO2) there was a statistically significant difference at the time of the first visit (p = 0.001), 0 (p = 0.001), 5 (p = 0.001) and 20 (p = 0.001). It is concluded that the local anesthetic can be used in normotensive patients during dental surgical procedures, and this slight increase in HR and SPO2 may be related to the anxiety and / or emotional stress of the patients.