Interações entre fármacos e nutrientes: ocorrência e manejo clínico

Abstract

Introduction: the diet provides nutrients needed to sustain the human body, so changes caused by diseases and infections lead to the use of drugs, which the combined use may interfere with the therapeutic efficacy. Objective: to present the clinical management, the occurrence and the various aspects of drug-nutrient interaction. Methodology: an integrative literature review, which was used databases to search for articles: BVS, MEDLINE, PubMed, LILACS and SciELO with keywords selected in the Descriptors in Health Sciences (DeCS) of Bireme: alimento – interactions drugs, medicines, clinic. studies were included that address the occurrence of drug interactions with dietary nutrients and the description of the clinical management, among case studies, reviews and clinical research, published in English, Portuguese or Spanish from 2008 to 2016. Results: in Administration medication with food there is the possibility of alterations in the pharmacokinetics or pharmacodynamics of the drug or nutrient by altering nutritional status or response to therapy. Overall, the strategies adopted must be pellicular each situation taking into account the clinical condition of the individual and drug characteristics in use associated with the metabolic needs of the body involved. As in the case of levodopa interact with amino acids that can be adopted the layout of diet schedule in order to administration of larger protein composition night. Conclusion: with this, we emphasize the importance of a multidisciplinary team to an indication of appropriate interventions to improve people’s lives.