Atividade antihiperglicêmica e antioxidante de lectina de Bryothamnion triquetrum em ratos com diabetes induzido por estreptozotocina

Abstract

Diabetes mellitus is a metabolic syndrome multiple origin, due to the lack of insulin and / or insulin inability properly exert its effects, causing an increase in blood glucose. Diabetes is because the pancreas is not able to produce the hormone insulin in sufficient quantities to meet the needs of the body, or because this hormone are not able to act appropriately (insulin resistance). Evidence suggests that caudadas injury by oxidative stress caused by free radicals contribute to the complications of diabetes by decreasing the enzymatic antioxidant defenses, and these are correlated with the severity of the pathological changes. Natural products have been the major source of inspiration for many areas of chemistry and science in general. Using, copying or modifying the molecules synthesized by living things, man has obtained innovations to your benefit in several areas, and among them, the production of drugs. Lectins seaweed are described as having anti-inflammatory activity, antimutagenic, anti-tumor, and anti-hypertensive properties. This study aimed to evaluate the antihiperglicemic and antioxidant activity of lectin Bryothamnion triquetrum (BTL) in vivo. For this evaluation Wistar rats were induced hyperglycemia using streptozotocine and the effectiveness and efficiency of treatment was evaluated from serum samples for measurement of glucose, total cholesterol, triglycerides, glutathione peroxidase, catalase and superoxide dismutase in the periods 7, 14 and 21 days after confirmation of hyperglycemia, being made excision of pancreas and liver on day 21 for histopathological analysis. The results presented show that BTL efficiency and effectiveness when compared to gold standard drug; glibenclamide promoting reduction in serum levels of glucose, total cholesterol, triglycerides and increasing the levels of antioxidant enzymes. In conclusion, these findings suggest that the BTL promotes a powerful protection to damage induced diabetes.