síntese, caracterização e estudo de reatividade dos complexos cis-[ru(bpy)2(4-bzpy)no](pf6)3 e cis-[ru(bpy)2(4-bzpy)co](pf6)2 (onde bpy = 2,2’-bipiridina e 4-bzpy = 4-benzoilpiridina).

Abstract

For a long time NO (nitric oxide) was known only as a toxic gas that in large concentrations caused damage to health. However, in the 1980s, studies have shown their participation in various physiological processes, including its activity as a mediation of the central nervous system, smooth muscle relaxation, participation in the ability of the immune system to destroy tumor cells and intracellular parasites, platelet adhesion and aggregation. Apparently, NO is not alone in many of these biological processes. Recently CO (carbon monoxide) is emerging as an important signaling molecule in these processes. Despite the beneficial effects, it is important to warn the danger of direct treatment with NO or CO gas, since it is difficult to determine the extent to which these gases are therapeutic, without causing toxic effects. This fact led recently the study of some metal complexes capable of releasing NO or CO in a controlled manner. This work was carried out the synthesis, characterization and evaluation of compounds of type cis-[Ru(bpy)2(4-bzpy)NO](PF6)3 and cis-[Ru(bpy)2(4-bzpy)CO](PF6)2 (where bpy = 2,2’-Bipyridina and 4-bzpy = 4-Benzoylpyridina). The characterization of the compounds was performed using electrochemical techniques (cyclic voltammetry), spectroscopic (vibrational spectroscopy in the IR region and electron spectroscopy), H and C nuclear magnetic resonance, X-ray diffraction monocrystals. The nitrosyl complex underwent reactivity testing as the release of NO0, showing good results as the electrochemical reduction, photochemical and biological front of a reducer. Once characterized, the carbonyl compound reactivity was also subjected to tests where the CO release was assessed by testing with myoglobin, using for this the spectrophotometric method.