Avaliação da atividade antimicrobiana dos compostos isolados da planta mitracarpus baturitensis frente à streptococcus mutans

Abstract

The Mitracapus (Rubiaceae) is a neotropical genus with three centers of diversity in Mexico, Brazil and the Caribbean. Regarding Mitracarpus baturitensis, there is still no report in literatura phytochemical and biological studies due to it being a newly discovered species. Therefore the aim of this study was to evaluate the antimicrobial activity of the ethanolic extract obtained composts of parts of flights Mitracarpus bauritensis against the bacteria Streptococcus mutans. Compounds ursolic acid (3β-hidroxi-urs-12-en-28-oico acid) and pomolic acid (28- O-β-D-glucopiranosil- acid pomólico ester) were isolated from the ethanolic extract by chromatographic assays, CCD and identified through the RNM. After identification were performed testing the minimum inhibitory concentration (MIC), minimum bactericidal concentration (CBM), curve of the time of the death, action antibiofilm, and assay attack of the biofilm. The increase inhibited bacterial growth at concentrations from 500 to 62,5 μg. mL-1 and bactericide concentration of 500 μg. mL-1. Furthermore, the AU had an effect on biofilm formation by reducing the biomass 97,37% same result is not obtained on the biofilm for 24 hours. Similar results were not obtained for the AP. Thus, AU can be analized as a candidate for biotechnological inputs impacting on research antimicrobial