Avaliação de Galactomanana da Adenanthera pavonina na Formação de Sistemas Matriciais

Abstract

The improvement in the development of modified release matrix systems strictly depends on the selection of an appropriate agent capable of controlling drug release, support the therapeutic action over time and / or releasing the drug at a particular tissue or organ damage. Among the various options, the polymers are versatile and promising agents to perform such function. In this study, galactomannan Adenanthera pavonina was investigated as a potential basis for the development of a system for controlled release hydrophilic matrix. To obtain a slow and prolonged release of rutin and mangiferin, hydrophilic matrices were prepared using different concentrations of polymer and different methods of preparation: the physical mixture and spray drier. The controlled release matrix containing rutin and natural gum (galactomannan) was compared with the most commercially used (containing hydroxypropyl methylcellulose [HPMC] as a control agent), as determining the most efficient method of preparation was done by comparing the matrices containing mangiferin. The rate of drug release in vitro as well as the release mechanism and the release kinetics were determined by zero- order, Higuchi and Korsmeyer equations. The analysis revealed a release of the drug release mechanism similar to the matrices developed. Systems containing galactomannan had a better control of drug release as compared with systems containing HPMC. Among the methods used in this work, the spray drier method is more efficient for the controlled release showing a slower release and continuous. New formulations for drug delivery from matrix systems were proposed.