Estudo Químico de Baccharis salzmannii DC

Abstract

This work presents the chemical study from the leaves of the species Baccharis salzmannii DC (Asteraceae) collected in the city of Jacobina, Bahia. The phytochemical investigation of the ethanol extract of leaves provided the isolation of the flavonoids 5,7,4 '-trihydroxy-flavone (apigenin) and 5,7,4'-trihydroxy-flavanone (narigenina), of the diterpene kaurenoic acid, two clerodane compounds, namely, (-)-(5R,6S,8R,9S,10R)-6,15,18,19-tetrahydroxy-cleroda-3-ene,(-)-(5R,6S,8R,9S,10R)-6,15,18-trihydroxy-cleroda-3-ene reported for the fist time in literature, and of the sesquiterpene patchoulane [7.10;1,5] patchou-4(12)-ene. For isolation of the metabolites were used usual chromatographic techniques as flash chromatography, exclusion chromatography on sephadex, thin layer chromatography and High Performance Liquid Chromatography. For structural elucidation of the isolated compounds was performed through the use spectrometrical techniques, infrared (IR), nuclear magnetic resonance (NMR) uni and bidimensional experiments, mass spectrometric (MS), and comparison with the literature data