Aplicação farmacêutica de inibidores de proteases : uma prospecção tecnológica

Abstract

Proteases are proteolytic enzymes that degrade proteins by specific peptide bonds break. Many proteases are associated with diseases like cancer, osteoporosis, neurodegenerative and inflammatory diseases, as well as parasitic diseases, bacterial or viral, since they are involved in the pathogenesis of various diseases that may be good therapeutic targets together with their inhibitors specific protease. This prospect was to analyze patents involving these inhibitors with pharmaceutical applications. Prospecting was carried out based on the patent applications filed in 4 analyzed databases, namely, National Institute of Industrial Property (INPI) of Brazil, the European Patent Office (EPO), United States Patent and Trademark Office (USPTO) and World Intellectual Property Organization (WIPO). After research it was found only 13 patents, showing that in 2007 was the peak of deposit and the United States and France stand as the largest depository, and demonstrating to the international classification A61K was most abundant, which is preparations for medical purposes, dental or hygienic. However, it was observed that there remains a small number of patents, necessitating a greater interest in the pharmaceutical application of protease inhibitors.