http://repositorio.ufc.br/handle/riufc/395 2026-04-18T08:05:39Z http://repositorio.ufc.br/handle/riufc/84461 Título: Nódulos linfoides medulares em pacientes portadores de síndromes mielodisplásicas: incidência, caracterização morfológica, imunohistoquímica e associação com critérios clínico-laboratorias, progressão da doença e sobrevida Autor(es): Magalhães, Silvia Maria Meira Tipo: Tese 2001-01-01T00:00:00Z http://repositorio.ufc.br/handle/riufc/75150 Título: Efeitos nefrotóxicos do veneno de Bothrops jararaca e estado da ação de antagonistas do PAF e da cicloxigenase no rim perfundido de rato Autor(es): Monteiro, Helena Serra Azul Abstract: Wephrotoxic Activitf ©f B&tAmjps jnaua Veaom aad th® Effect® of PAF ÂntagoBists and C^cloo^yfenase Inibitors in tbe Rat Perfased Kidneys. Helena Serra Azul Monteiro UNICAMP/UFC, 1990. This work evaluates nephrotoxic effects of the venom of Botimps jararaca , a snake responsible for many snake bite accidents in the Northeast of Brazil and thus is an important public health problem in our country. The model used was the isolated perfased rat kidney. We used a modified Krebs-Henseleit solution with added albumin at 6g% which produced more reliable than albumin concentrations of 2 and 4g%. The parameters studied were: perfusion pressure (PP), renal vascular resístance (RVR), urinary flow (UF), glomerular filtration rate (GFR), sodium transport (TNa+), potassium transport (TK+), free water dearan.ce (CHgO), proximal transport of sodium (pTNa+) and distai transport of sodium (dTNa+). The results for the control group were: PP»149,17 ± 4,03 mmHg, RVR®6,38 ± 0,68 mmHg/mlAgAminA UF«0,26 ± 0,005 mlAgAminA GFR=1,13 ± 0,21 mlAgAminA TNa+= 136,13 ± 28,68 uEq.gAminA %TNa+«78,53± 1,91. In the kidneys treated by the venom (lOmgfrnl) we observed, at 30 min of perfusion, a marked decrease in these parameters: PP=100,50 ± 10,81 mmHg.ml' KgAmind (45%); RVR=3,92 ± 0,47 mmHg/mlAgAmin'Í (31,10%); UF»0,02 ± 0,05 mlAgAmin-1 (85%), GFR-0,06 + 0,02 mlAgAmin "1 (90%); TNa^-5,30 ± 2,73piEq.gAmin'l (90%). In an attempt to block these toxic effects we have used BN 52021 and WEB 2086, two drugs which are platelet activating factor (PAF) antagonists. BN 52021 did not protect against the toxic effects of the venom, except in blocking the decrease in sodium and potassium in the tissues. WEB 2086 blocked the urinary flow and GFR changes by the venom and even elevated these parameters in relation to the Controls. The perfusion pressure was not reversed. CHgO, dTNa+ and %dTNa+ all presented negative values when compared to Controls. We also found that indomethacin antagonized the toxic effects of the venom found in UF, GFR, RVR, and partially blocked PP. The venom also produced a decrease in tissue Na+ and K+, which in tum was blocked by BN 52021, WEB 2086 and indomethacin. Histopathological study revealed that in both groups, treated and untreated by the venom, there was a tabular dilatation and tumefaction. These effects could be the result of the perfusion itself. However, in the groups treated -viii- IfffíiTO with the venom we found peater amounts of protein inside the tabules and in the ^omeralar spaces. We also found a tabular necrosis in two kidneys. With this technique we nowhave a model to stady nepbrotwdc dnçs. We conciude that the venom produces significant alterations of UF, GFR, RVR, PP, TNa4; %TNa+ and %TK.4', with a decrease in leveis oftissue Na+ and K+. Tipo: Tese 1990-01-01T00:00:00Z http://repositorio.ufc.br/handle/riufc/72529 Título: Tratamento da insuficiência cardíaca congestiva por uma glicóside pura do Nerium oleander (Folinerina) Autor(es): Chiaverini, Reinaldo Tipo: Tese 1939-01-01T00:00:00Z http://repositorio.ufc.br/handle/riufc/62479 Título: Programa de treinamento sobre a intervenção terapêutica relaxamento, imagens mentais e espiritualidade (rime) para re-significar a dor espiritual de pacientes terminais Autor(es): Elias, Ana Catarina Tavares de Araújo Abstract: In tbis essay of Mastership we developed the study of the Therapeutical Intervention “Relaxation, Mental Images and Spirituality” (RIME) applied for terminal patients. The continuity for the research in the Doctorship consisted in operating a Course of Capadtance on the RIME Intervention usage by the health area professionals (Phasel) and on the analysis of the living experiences of these professionals in the application and evaluation of the RIME use in the patients (Phase2). The participants were a nurse, a female doctor, three psychologists and an altemative volunteer therapist, all experienced ones or scholars at Palliative Cares, they were selected by invitation and were in charge of caring of eleven terminal outpatients in public hospitais of Campinas, Piracicaba and São Paulo. This study had as a theory methodological base the Action-Research and the Phenomenology. The qualitative results were caught through the Semi-Structured Interview, the Structural Questionnaire and the Diary, and they were analyzed by the Contents Analysis method through the Thematically Analysis techniques. It is descriptive through the data, which were caught by the Analogical Visual Scale instrument of Welfare-AVS, in-color faces model, by using the Wilcoxon test. In the analysis of the professionals experiences were found five categories and fifteen sub-categories. In the analysis of the Spiritual Pain constitution, six categories were found with eleven sub-categories. In the application of the RIME was observed statistically expressive difference (p<0,0001) that is, at the end of each session the patients reported a greater levei of welfare than at the beginning, indicating that the RIME favors the re-signification of the Spiritual Pain in the terminal patients. The purposed training program showed itself effective in preparing health area professionals for the use of the RIME Intervention, qualifying them to care and give spiritual assistance inside an academic perspective. Tipo: Tese 2005-01-01T00:00:00Z