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dc.contributor.authorRodrigues, Felipe A. R.-
dc.contributor.authorOliveira, Augusto C. A.-
dc.contributor.authorCavalcante, Bruno C.-
dc.contributor.authorPessoa, Claudia-
dc.contributor.authorPinheiro, Alessandra C.-
dc.contributor.authorSouza, Marcus V. N. de-
dc.date.accessioned2014-08-11T15:56:29Z-
dc.date.available2014-08-11T15:56:29Z-
dc.date.issued2014-03-
dc.identifier.citationRODRIGUES, F. A. R. et al. Biological evaluation of isoniazid derivatives as an anticancer class. Scientia Pharmaceutica, v. 82, n. 1, p. 21-8, mar. 2014.pt_BR
dc.identifier.issn0036-8709 Impresso-
dc.identifier.urihttp://www.repositorio.ufc.br/handle/riufc/8673-
dc.description.abstractA series of thirty-two isoniazid derivatives have been evaluated for their activity against four human cancer cell lines with potent cytotoxicity (IC50 ranging from 0.61 to 3.36 μg/mL). The structure-activity relationship (SAR) analysis indicated the number, the positions, and the types of substituents attached to the aromatic ring as being critical factors for the biological activity. Briefly, we observed that the presence of a hydroxyl group on the benzene ring plays an important role in the anticancer activity of this series, especially when it is located in ortho-position. Among the thirty-two compounds, three displayed good cytotoxic activity when compared to the reference drug doxorubicin and are thus being considered leading compounds of this new class.pt_BR
dc.language.isoenpt_BR
dc.publisherScientia Pharmaceuticapt_BR
dc.subjectIsoniazidapt_BR
dc.subjectNiacinapt_BR
dc.titleBiological evaluation of isoniazid derivatives as an anticancer classpt_BR
dc.typeArtigo de Periódicopt_BR
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