Avaliação da atividade antimicrobiana da dipirona

Abstract

Dipyrone was evaluated for antimicrobial activity in five pharmaceutical drops. The aim of this study was test an alleged antimicrobial activity reported by previous works. The agar diffusion method was employed using drilled holes in the layer of culture medium inoculated with micro-organisms and observed the formation of an inhibition zone by the presence of an active substance against the test organism. The samples were tested against the microorganisms Staphylococcus aureus (ATCC 6538), Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 10536), Escherichia coli (ATCC 35218), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and Kocuria rhizophila (ATCC 9341). Antimicrobial effect of the products A, B, C, D and E containing was showed dipyrone, against all organisms tested in the concentrations of 75 mg/mL, 100 mg/ml and in the original concentration of products in association with other active ingredients. The results points to a more pronounced activity of the undiluted product. The D product in the concentracions tested showed antimicrobial activity against all microorganisms. The C product was less effective when compared to other products. The dipyrone raw material showed no activity against Pseudomonas aeruginosa and Kocuria rhizophila. The results obtained showed the antimicrobial activity of dipyrone products in the pharmaceutical form droplets. Future studies are needed, to assess this effect in trademarks other dipyrone and other pharmaceutical forms.