Desenvolvimento e avaliação da estabilidade preliminar de repelentes de efeito prolongado com ativos de origem natural

Abstract

Arboviruses, such as, dengue fever, chikugunya, zika and others, are transmitted by bites of female mosquitoes of the culicidae family. These diseases have high morbidity and mortality in our county. A way to prevent these mosquito bites is by using repellents. However, many repellents in the market today use synthetic repellent actives which presente restriction uses in children, pregnant women and hypersensitivity people. For this reason, repellents containing essential oils are being studied. These oils have shown repellent activity. The challenge is to develop a formulation that is effective in fixing these compounds, increasing the duration of the repellent activity. In this study several formulation bases were elaborated until developing one that presented satisfactory results with the most appropriate components. With this base, three formulations were prepared, one containing Cymbopogon nardus oil, another with Lippia sidoides oil, and finally, one containing Eucalyptus globulus oil. A preliminary stability test was performed, where the samples from each formulation were submitted to extreme temperature conditions. The emulsions prepared were also evaluated according to physicochemical parameters, such as appearance, color, odor, pH and viscosity. In addition, microbiological tests were performed, such as plaque assay method and pathogenic microorganism research. The results of all test were satisfactory. So, the incorporation of essential oils of citronella, rosemary-pepper and eucalyptus globulus in bases containing carbomer and PVP k 90 for a gel cream was possible. However, efficacy tests are still needed to prove the repellent activity of the formulation for later commercialization.