Síntese, caracterização e estudo das propriedades fotoquímicas de novos complexos do tipo cis-[Ru(phen)2(SO3)L]0/2-, em que L=CO, H2O ou SO3 2-

Abstract

Currently, some inorganic complexes are efficiently employed in the treatment of various diseases. Many of these complexes are referred to as metallodrugs, as they contain a metal center in their structure and also exhibit pharmacological properties. Coordination compounds present promising pharmaceutical applications due to their wide structural variety and the numerous possibilities for interactions. In this context, it is essential to emphasize the importance of ligand selection in modulating these novel ruthenium complexes. For their application as antimicrobial agents, the sulfite ion (SO₃²⁻) appears to be promising, as it has been used as a preservative in food and beverages. Another interesting ligand is CO, which also exhibits antimicrobial activity, in addition to acting as a regulator of the cardiovascular, immune, and nervous systems. Thus, with the aim of investigating these pharmacological properties, ruthenium complexes with phenanthroline, containing sulfite ion, carbon monoxide, and H₂O, were synthesized. The compounds were characterized using electrochemical techniques (cyclic voltammetry), spectroscopic methods (infrared vibrational spectroscopy and electronic spectroscopy), nuclear magnetic resonance spectroscopy of ¹H and ¹³C, and single-crystal X-ray diffraction. After characterization, the photochemical properties of these compounds were evaluated. Specifically, for the metal carbonyl complex, reactivity tests were carried out to assess CO release through myoglobin assays, using a spectrophotometric method.