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Type: Artigo de Periódico
Title: Evaluation of the modulatory and antibacterial activity of the ethanolic extract and fractions of Duguetia furfuracea A. St.-Hil.
Authors: Fernandes, Cicera Norma
Sousa, Heloisa Helena Ferreira
Souza, Celestina Elba Sobral
Guedes, Glaucia Morgana Melo
Figueredo, Fernando Gomes
Tintino, Saulo Relison
Costa, José Galberto Martins
Coutinho, Henrique Douglas Melo
Menezes, Irwin Rose Alencar
Felipe, Cícero Francisco Bezerra
Kerntopf, Marta Regina
Borges, Maria Cristina Melo
Keywords: Aminoglicosídeos;Plantas Medicinais
Issue Date: Jan-2014
Publisher: African Journal of Pharmacy and Pharmacology
Citation: FERNANDES, C. N. et al. Evaluation of the modulatory and antibacterial activity of the ethanolic extract and fractions of Duguetia furfuracea A. St.-Hil. African Journal of Pharmacy and Pharmacology, v. 8, n. 1, p. 16-20, jan. 2014.
Abstract: Medicinal plants have been the subject of research in several countries such as Brazil. The Duguetia furfuracea A. St.-Hil., popularly known as araticum-bravo, ata-brava and ata de lobo, has been used in folk medicine as anti-rheumatic drugs, for the treatment of renal dysfunction, spinal pain and stomach, and against pediculosis. This work aimed to analyze the antibacterial effect of the crude extract and fractions obtained from the leaves of D. furfuracea. The characterization of secondary metabolites was carried out through phytochemical prospection, being checked for the presence of tannins, flavonoids and alkaloids. The minimum inhibitory concentration (MIC) was determined by using broth microdilution method and its modulating activity of antibiotic activity in sub-inhibitory (MIC/8) concentration. When standard bacterial strain is used for the MIC and multidrug-resistant strains of modulation, all samples had a MIC ≥ 1024 μg/ml. The samples when combined with aminoglycosides demonstrated synergistic activity against the Escherichia coli 27 and Staphylococcus aureus 358. The results of this study indicate the species D. furfuracea as a promising source in combating bacterial multidrug resistance, increasing the potential of antibiotics.
ISSN: 1996-0816
Appears in Collections:DFIFA - Artigos publicados em revista científica

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