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dc.contributor.authorNascimento, Raimundo Regivaldo Gomes do-
dc.contributor.authorPimenta, Antônia Torres Ávila-
dc.contributor.authorLima Neto, Pedro de-
dc.contributor.authorCândido Júnior, José Roberval-
dc.contributor.authorLotufo, Leticia Veras Costa-
dc.contributor.authorFerreira, Elthon Gois-
dc.contributor.authorTinoco, Luzineide Wanderley-
dc.contributor.authorBraz Filho, Raimundo-
dc.contributor.authorSilveira, Edilberto Rocha-
dc.contributor.authorLima, Mary Anne Sousa-
dc.date.accessioned2023-05-15T16:24:04Z-
dc.date.available2023-05-15T16:24:04Z-
dc.date.issued2015-
dc.identifier.citationNASCIMENTO, Raimundo Regivaldo Gomes do; PIMENTA, Antônia Torres Ávila; LIMA NETO, Pedro de; CÂNDIDO JÚNIOR, José Roberval; LOFUTO, Leticia Veras Costa; FERREIRA, Elthon Gois; TINOCO, Luzineide Wanderley; BRAZ FILHO, Raimundo; SILVEIRA, Edilberto Rocha; LIMA, Mary Anne Sousa. New alkaloids from margaritopsis carrascoana (rubiaceae). Journal of the Brazilian Chemical Society, v. 26, n. 6, p. 1152-1159, 2015.pt_BR
dc.identifier.issn1678-4790-
dc.identifier.otherDOI: http://dx.doi.org/10.5935/0103-5053.20150079.-
dc.identifier.urihttp://www.repositorio.ufc.br/handle/riufc/72270-
dc.description.abstractTwo new alkaloids containing Nb-methyl-triptamine units linked to bis-quinoline moieties, N-8”-formyl-calycosidine and N-8”-methyl-N-1’-demethyl-iso-calycosidine, were isolated from the aerial part of Margaritopsis carrascoana, along with known calycosidine and hodgkinsine. The cytotoxicity of the isolated alkaloids has been evaluated against cancer cell lines. The first two compounds showed only weak activity against HL-60 cell line, while hodgkinsine was the most active compound against HCT-116, OVCAR-8, HL-60 and SF-295 cancer cell lines. The structures of the isolated compounds were established by spectroscopic and molecular mechanical methods.pt_BR
dc.language.isoenpt_BR
dc.publisherJournal of the Brazilian Chemical Societypt_BR
dc.subjectMargaritopsis carrascoanapt_BR
dc.subjectRubiaceae alkaloidspt_BR
dc.subjectN-8”-methyl-N-1’-demethyl- iso-calycosidinept_BR
dc.subjectMargaritopsis carrascoanapt_BR
dc.subjectAlcaloides de rubiaceaept_BR
dc.titleNew alkaloids from margaritopsis carrascoana (rubiaceae)pt_BR
dc.typeArtigo de Periódicopt_BR
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