Use este identificador para citar ou linkar para este item: http://repositorio.ufc.br/handle/riufc/62923
Tipo: Artigo de Periódico
Título: The human pandemic coronaviruses on the show: the spike glycoprotein as the main actor in the coronaviruses play
Autor(es): Souza, Pedro F. N.
Mesquita, Felipe P.
Amaral, Jackson Lima
Landima, Patrícia G. C.
Lima, Karollyny R. P.
Costa, Marília B.
Farias, Izabelle Rocha
Lima, Luina B.
Montenegro, Raquel C.
Palavras-chave: Coronavírus;Glicoproteínas;Glycoproteins;Covid-19
Data do documento: 2021
Instituição/Editor/Publicador: International Journal of Biological Macromolecules
Citação: SOUZA, Pedro F. N. et al. The human pandemic coronaviruses on the show: The spike glycoprotein as the main actor in the coronaviruses play. International Journal of Biological Macromolecules, v. 179, p. 1–19, may, 2021. Disponível em: http://www.repositorio.ufc.br/handle/riufc/62923. Acesso em: 13/12/2021.
Abstract: Three coronaviruses (CoVs) have threatened theworld population by causing outbreaks in the last two decades. In late 2019, the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged and caused the coronaviruses to disease 2019 (COVID-19), leading to the ongoing global outbreak. The other pandemic coronaviruses, SARS-CoV and Middle East respiratory syndrome CoV (MERS-CoV), share a considerable level of similarities at genomic and protein levels. However, the differences between them lead to distinct behaviors. These differences result from the accumulation of mutations in the sequence and structure of spike (S) glycoprotein, which plays an essential role in coronavirus infection, pathogenicity, transmission, and evolution. In this review, we brought togethermany studies narrating a sequence of events and highlighting the differences among S proteins fromSARS-CoV, MERS-CoV, and SARS-CoV-2. Itwas performed here, analysis of S protein sequences and structures from the three pandemic coronaviruses pointing out the mutations among them and what they come through. Additionally, we investigated the receptor-binding domain (RBD) from all S proteins explaining themutation and biological importance of all of them. Finally,we discuss the mutation in the S protein fromseveral newisolates of SARS-CoV-2, reporting their difference and importance. This reviewbrings into detail howthe variations in S protein that make SARS-CoV-2more aggressive than its relatives coronaviruses and other differences between coronaviruses.
URI: http://www.repositorio.ufc.br/handle/riufc/62923
ISSN: 0141-8130
Aparece nas coleções:COVID-19 - Trabalhos relacionados
PPGF - Artigos publicados em revistas científica

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
2021_art_pfnsouza.pdf2,87 MBAdobe PDFVisualizar/Abrir


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.