Please use this identifier to cite or link to this item:
Title in Portuguese: A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi
Title: A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi
Author: Pacheco, Christina
Felipe, Stela Mirla da Silva
Soares, Milca Magalhães Dias de Carvalho
Alves, Juliana Osório
Soares, Paula Matias
Leal-Cardoso, José Henrique
Loureiro, Adriano César Carneiro
Ferraz, Alex Soares Marreiros
Carvalho, Denise Pires de
Ceccatto, Vânia Marilande
Keywords: Ontologia genética do exercício
Genômica do exercício
Genes ligados ao exercício físico
Fisiologia do exercício molecular
Transcriptoma de exercício físico
Issue Date: 2018
Citation: PACHECO, Christina et al. A Compendium of Physical Exercise-related Human Genes: An'OMIC Scale Analysi, BIOLOGY OF SPORT, [s. l.], v.35, p.1-11, 2018
Abstract: : Regular exercise is an exogenous factor of gene regulation with numerous health benefits. The study aimed to evaluate human genes linked to physical exercise in an ‘omic scale, addressing biological questions to the generated database. Three literature databases were searched with the terms ‘exercise’, ‘fitness’, ‘physical activity’, ‘genetics’ and ‘gene expression’. For additional references, papers were scrutinized and a textmining tool was used. Papers linking genes to exercise in humans through microarray, RNA-Seq, RT-PCR and genotyping studies were included. Genes were extracted from the collected literature, together with information on exercise protocol, experimental design, gender, age, number of individuals, analytical method, fold change and statistical data. The ‘omic scale dataset was characterized and evaluated with bioinformatics tools searching for gene expression patterns, functional meaning and gene clusters. As a result, a physical exercise-related human gene compendium was created, with data from 58 scientific papers and 5.147 genes functionally correlated with 17 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. While 50.9% of the gene set was up-regulated, 41.9% was down-regulated. 743 up- and 530 down-regulated clusters were found, some connected by regulatory networks. To summarize, up- and down-regulation was encountered, with a wide genomic distribution of the gene set and up- and down-regulated clusters possibly assembled by functional gene evolution. Physical exercise elicits a widespread response in gene expression.
metadata.dc.type: Artigo de Periódico
Appears in Collections:IEFES - Artigos publicados em revistas científicas

Files in This Item:
File Description SizeFormat 
2018_art_cpacheco.pdf951,3 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.