Use este identificador para citar ou linkar para este item: http://repositorio.ufc.br/handle/riufc/57881
Tipo: Artigo de Periódico
Título: Impact of apolipoprotein E genetic polymorphisms on liver disease: an essential review
Autor(es): Nascimento, José Carlos Rodrigues
Matos, Gabriella A.
Pereira, Lianna C.
Mourão, Anderson E.C.C.B.
Sampaio, Aline M.
Oriá, Reinaldo B.
Toniuttoc, Pierluigi
Palavras-chave: Apolipoproteínas E;Apolipoprotein E;Liver cirrhosis;Cirrose Hepática;Liver diseases;Hepatopatias;Liver transplantation;Transplante de Fígado
Data do documento: Jan-2020
Instituição/Editor/Publicador: Annals of Hepatology
Citação: NASCIMENTO, J. C. R. et al. Impact of apolipoprotein E genetic polymorphisms on liver disease: An essential review. Annals of Hepatology, v. 19, n. 1, p. 24-30, 2020. Disponível em: https://www.sciencedirect.com/science/article/pii/S1665268119322185?via%3Dihub. Acesso em: 20 abr. 2021.
Abstract: Cirrhosis is an advanced stage of liver disease, compromising liver function with systemic health implications and poor quality of life. Hepatitis C virus (HCV) infection and alcoholic liver disease are the main causes of this pathology. However, since genetic factors may play a large role in the progression and severity of liver disease, and as apolipoprotein E (apoE) has been recognised to be mainly synthesised in the liver, apoE polymorphism studies are important to better understand the causal mechanisms in liver diseases. In this review, we summarise up-to-date studies addressing how apoE polymorphisms influence liver cirrhosis and liver transplantation outcomes and potential protective mechanisms. Although more clinical studies are needed to support these findings, the apoE 4 allele seems to be protective against the progression of liver cirrhosis in the majority of aetiologies and the postoperative serum apoE phenotype of the transplanted subject receptors was converted to that of the donor, indicating that >90% of apoE in plasma is synthesised in the hepatic system.
URI: http://www.repositorio.ufc.br/handle/riufc/57881
ISSN: 1665-2681
Aparece nas coleções:DMC - Artigos publicados em revistas científicas

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