Use este identificador para citar ou linkar para este item:
http://repositorio.ufc.br/handle/riufc/5724
Registro completo de metadados
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Honório Junior, José Eduardo Ribeiro | - |
dc.contributor.author | Vasconcelos, Germana Silva | - |
dc.contributor.author | Rodrigues, Francisca Taciana Sousa | - |
dc.contributor.author | Sena Filho, José Guedes | - |
dc.contributor.author | Barbosa-Filho, José Maria | - |
dc.contributor.author | Aguiar, Carlos Clayton Torres | - |
dc.contributor.author | Leal, Luzia Kalyne Almeida Moreira | - |
dc.contributor.author | Soares, Pedro Marcos Gomes | - |
dc.contributor.author | Woods, David John | - |
dc.contributor.author | Fonteles, Marta Maria de França | - |
dc.contributor.author | Vasconcelos, Silvânia Maria Mendes | - |
dc.date.accessioned | 2013-09-03T10:48:39Z | - |
dc.date.available | 2013-09-03T10:48:39Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | HONÓRIO JUNIOR, J. E. R et al. Monocrotaline : histological damage and oxidant activity in brain areas of mice. Oxidative Medicine and Cellular Longevity, v. 2012, p. 1-10, 2012. | pt_BR |
dc.identifier.issn | 1942-0900 | - |
dc.identifier.uri | http://www.repositorio.ufc.br/handle/riufc/5724 | - |
dc.description.abstract | This work was designed to study MCT effect in histopathological analysis of hippocampus (HC) and parahippocampal cortex (PHC) and in oxidative stress (OS) parameters in brain areas such as hippocampus (HC), prefrontal cortex (PFC), and striatum (ST). Swiss mice (25–30 g) were administered a single i.p. dose of MCT (5, 50, or 100 mg/kg) or 4% Tween 80 in saline (control group). After 30 minutes, the animals were sacrificed by decapitation and the brain areas (HC, PHC, PFC, or ST) were removed for histopathological analysis or dissected and homogenized for measurement of OS parameters (lipid peroxidation, nitrite, and catalase) by spectrophotometry. Histological evaluation of brain structures of rats treated with MCT (50 and 100 mg/kg) revealed lesions in the hippocampus and parahippocampal cortex compared to control. Lipid peroxidation was evident in all brain areas after administration of MCT. Nitrite/nitrate content decreased in all doses administered in HC, PFC, and ST. Catalase activity was increased in the MCT group only in HC. In conclusion, monocrotaline caused cell lesions in the hippocampus and parahippocampal cortex regions and produced oxidative stress in the HC, PFC, and ST in mice. These findings may contribute to the neurological effects associated with this compound. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | Oxidative medicine and cellular longevity | pt_BR |
dc.subject | Monocrotalina | pt_BR |
dc.subject | Ratos | pt_BR |
dc.title | Monocrotaline : histological damage and oxidant activity in brain areas of mice | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
Aparece nas coleções: | DFIFA - Artigos publicados em revista científica |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
2012_art_ftsrodrigues.pdf | 6,56 MB | Adobe PDF | Visualizar/Abrir |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.