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dc.contributor.authorHonório Junior, José Eduardo Ribeiro-
dc.contributor.authorVasconcelos, Germana Silva-
dc.contributor.authorRodrigues, Francisca Taciana Sousa-
dc.contributor.authorSena Filho, José Guedes-
dc.contributor.authorBarbosa-Filho, José Maria-
dc.contributor.authorAguiar, Carlos Clayton Torres-
dc.contributor.authorLeal, Luzia Kalyne Almeida Moreira-
dc.contributor.authorSoares, Pedro Marcos Gomes-
dc.contributor.authorWoods, David John-
dc.contributor.authorFonteles, Marta Maria de França-
dc.contributor.authorVasconcelos, Silvânia Maria Mendes-
dc.date.accessioned2013-09-03T10:48:39Z-
dc.date.available2013-09-03T10:48:39Z-
dc.date.issued2012-
dc.identifier.citationHONÓRIO JUNIOR, J. E. R et al. Monocrotaline : histological damage and oxidant activity in brain areas of mice. Oxidative Medicine and Cellular Longevity, v. 2012, p. 1-10, 2012.pt_BR
dc.identifier.issn1942-0900-
dc.identifier.urihttp://www.repositorio.ufc.br/handle/riufc/5724-
dc.description.abstractThis work was designed to study MCT effect in histopathological analysis of hippocampus (HC) and parahippocampal cortex (PHC) and in oxidative stress (OS) parameters in brain areas such as hippocampus (HC), prefrontal cortex (PFC), and striatum (ST). Swiss mice (25–30 g) were administered a single i.p. dose of MCT (5, 50, or 100 mg/kg) or 4% Tween 80 in saline (control group). After 30 minutes, the animals were sacrificed by decapitation and the brain areas (HC, PHC, PFC, or ST) were removed for histopathological analysis or dissected and homogenized for measurement of OS parameters (lipid peroxidation, nitrite, and catalase) by spectrophotometry. Histological evaluation of brain structures of rats treated with MCT (50 and 100 mg/kg) revealed lesions in the hippocampus and parahippocampal cortex compared to control. Lipid peroxidation was evident in all brain areas after administration of MCT. Nitrite/nitrate content decreased in all doses administered in HC, PFC, and ST. Catalase activity was increased in the MCT group only in HC. In conclusion, monocrotaline caused cell lesions in the hippocampus and parahippocampal cortex regions and produced oxidative stress in the HC, PFC, and ST in mice. These findings may contribute to the neurological effects associated with this compound.pt_BR
dc.language.isoenpt_BR
dc.publisherOxidative medicine and cellular longevitypt_BR
dc.subjectMonocrotalinapt_BR
dc.subjectRatospt_BR
dc.titleMonocrotaline : histological damage and oxidant activity in brain areas of micept_BR
dc.typeArtigo de Periódicopt_BR
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