Comparação dos graus de fibrose hepática na hepatite C crônica (HCC) medidos por métodos de elastrografia e de sorologia: ARFI e Fibroscan vs APRI e FIB4

Abstract

For treating chronic hepatitis C (CHC) we should know the hepatic fibrosis degree, which is better evaluated through hepatic biopsy. However, non-invasive elastography and serological methods have being preferred. Aims: Compare the concordance between two elastography and two serologicals methods. Methodology: From January/2014-December/2016 CHC patients with elastography (FibroScan and ARFI) were enrolled. Their fibrotic degrees were grouped (F0/F1; F2/F3/F4) and compared with fibrotic degrees calculated by APRI and FIB4, grouped (F0/F1; F2/F3/F4). Comparisons: FibroScan with APRI, FibroScan with FIB-4, ARFI with APRI, ARFI with FIB-4 e APRI with FIB4. Analysis: Kappa concordance. Results: 73 patients (54 male); mean age of 58 (32 – 81) years-old, had elastography (31 FibroScan and 42 ARFI). For comparisons APRI and FIB4 were calculated. Comparisons between FibroScan and APRI or FIB4 showed better concordance in high degrees of fibrosis (group F2/F3/F4). APRI and FIB4 underestimated the fibrosis in relation to FibroScan. ARFI compared to APRI and FIB4 showed poor concordance. Concordance between ARFI and APRI is better in the low degrees (group F0/F1) and is absent in high degrees of fibrosis (group F2/F3/F4). FIB4 overestimated the fibrosis in relation to ARFI. Conclusion: The concordance of serologicals and elastography methods vary from an absence of concordance to a moderate concordance.