Prevalence of Helicobacter pylori genotypes (vacA, cagA, cagE and virB11) in gastric cancer in Brazilian’s patients : an association with histopathological parameters

Abstract

Purpose: To investigate the frequency and the association of vac A alleles, cag A, cag E and vir B11 genes of Helicobacter pylori from patients with gastric cancer, considering the clinic histopathological parameters. Methods : One hundred and one gastric adenocarcinoma tissues were assessed by PCR to detect H. pylori and vac A alleles, cag A, cag E and vir B11. Results : The distribution of cases according to the presence of the genes studied showed that the group containing vac A s1m1, cag A, cag E and vir B11 H. pylori genes was significantly more frequent, followed by the group with at least one marker on the right side and left of the island. They were also present in the early stages and were the most frequent in nearly all histopathological grades. Conclusions : This study verified that vac As1m1 and cag -PAI genes, cag A, cag E and vir B11 are important H. pylori markers for gastric cancer development. Also, this study corroborates the importance of cag E and cag A together as cag -PAI marker