Síntese e caracterização de MOFs para aplicação biomédica

Abstract

The use of MOFs as controlled release drug coating structures can have great advantages as these hybrid structures have selective active sites and porous crystalline structure with wide range for different applications besides the metallic center which can be used for biological marking. Simvastatin is a statin class drug that is used to lower cholesterol and produce bone morphogenetic proteins (stimulate bone restructuring), which is a desired function for periodontal treatment and can be optimized with controlled release of the drug in the body, since this treatment is long lasting, which varies according to the severity of the patient. The objective of this work is to synthesize different MOFs and to combine one of them with a drug (Simvastatin) for later characterization of the structures and biological tests. The synthesis of the ZIF’s was carried out by a unique methodology, which begins with the mixing of the reagents (inorganic salt and organic binder), proceeds with mechanical stirring through magnetic bar for one hour and ends with drying and storage of the sample. SV was isolated from commercial tablets, treated with methanol and centrifuged with subsequent drying and storage. The junction between the ZIF and the SV occurred through a methodology similar to that of the synthesis of the ZIF, except that the agitation occurred at 24h and 72h. The characterization of the isolated samples and the mixture resulting from 24 and 72h agitation was performed by X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy, UV / Visible Spectroscopy, Thermogravimetry (TG) and Differential Scan Calorimetry (DSC). The results indicate the presence of crystalline structures consistent with the patterns, the absence of destructive processes and interactions, the formation of bands related to the compounds that were supposed to be present and a possible inter-structural interaction due to the formation of new thermal degradation bands.