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dc.contributor.authorCaetano, Erica Pacheco-
dc.contributor.authorBrilhante, Raimunda S.N.-
dc.contributor.authorFechine, Maria A.B.-
dc.contributor.authorMesquita, Jacó R.L.-
dc.contributor.authorCordeiro, Rossana A.-
dc.contributor.authorRocha, Marcos F.G.-
dc.contributor.authorMonteiro, André J.-
dc.contributor.authorLima, Rita A.C.-
dc.contributor.authorPereira, Juliana F.-
dc.contributor.authorCastelo-Branco, Débora S.C.M.-
dc.contributor.authorCamargo, Zoilo Pires de-
dc.contributor.authorSidrim, José J.C.-
dc.date.accessioned2013-06-07T14:11:26Z-
dc.date.available2013-06-07T14:11:26Z-
dc.date.issued2012-08-
dc.identifier.citationCAETANO, É. P. et al. Histoplasmosis in HIV-positive patients in Ceará, Brazil : clinical-laboratory aspects and in vitro antifungal susceptibility of Histoplasma capsulatum isolates. Transactions of the Royal Society of Tropical Medicine and Hygiene, Oxford, v. 106, n. 8, p. 484-88, ago. 2012.pt_BR
dc.identifier.issn0035-9203-
dc.identifier.urihttp://www.repositorio.ufc.br/handle/riufc/4949-
dc.language.isoenpt_BR
dc.publisherTransactions of the Royal Society of Tropical Medicine and Hygienept_BR
dc.subjectHIVpt_BR
dc.subjectHistoplasmosept_BR
dc.subjectHistoplasmapt_BR
dc.titleHistoplasmosis in HIV-positive patients in Ceará, Brazil : clinical-laboratory aspects and in vitro antifungal susceptibility of Histoplasma capsulatum isolatespt_BR
dc.typeArtigo de Periódicopt_BR
dc.description.abstract-ptbrThis study contains a descriptive analysis of histoplasmosis in AIDS patients between 2006 and 2010 in the state of Ceará, Brazil. Additionally, the in vitro susceptibility of Histoplasma capsulatum isolates obtained during this period was assessed. We report 208 cases of patients with histoplasmosis and AIDS, describing the epidemiological, clinical, laboratory and therapeutic aspects. The in vitro antifungal susceptibility test was carried out by the microdilution method, according to Clinical and Laboratory Standards Institute, with H. capsulatum in the filamentous and yeast phases, against the antifungals amphotericin B, fluconazole, itraconazole, voriconazole and caspofungin. In 38.9% of the cases, histoplasmosis was the first indicator of AIDS and in 85.8% of the patients the CD4 cell count was lower than 100 cells/mm3. The lactate dehydrogenase levels were high in all the patients evaluated, with impairment of hepatic and renal function and evolution to death in 42.3% of the cases. The in vitro susceptibility profile demonstrated there was no antifungal resistance among the isolates evaluated. There was a significant increase in the number of histoplasmosis cases in HIV-positive patients during the period surveyed in the state of Ceará, northeastern Brazil, but no antifungal resistance among the recovered isolates of H. capsulatum.pt_BR
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