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dc.contributor.authorRocha, Sabrina Gabriele Maia Oliveira-
dc.contributor.authorCorreia, Luciano Lima-
dc.contributor.authorCunha, Antônio José Lêdo Alves da-
dc.contributor.authorRocha, Hermano Alexandre Lima-
dc.contributor.authorMadeiro, Álvaro Jorge Madeiro-
dc.contributor.authorCampos, Jocileide Sales-
dc.contributor.authorBandeira, Tereza de Jesus Pinheiro Gomes-
dc.contributor.authorNascimento, Lucas Silveira do-
dc.contributor.authorSilva, Anamaria Cavalcante e-
dc.date.accessioned2020-01-21T18:21:13Z-
dc.date.available2020-01-21T18:21:13Z-
dc.date.issued2019-08-
dc.identifier.citationROCHA, Sabrina Gabriele Maia Oliveira et al. Zika virus infection and microcephaly: a case-control study in Brazil. Annals of Global Health, v.85, n. 1, p. 1–11, aug. 2019.pt_BR
dc.identifier.issn2214-9996-
dc.identifier.urihttp://www.repositorio.ufc.br/handle/riufc/49466-
dc.description.abstractBackground: Brazil presented an alarming number of newborns with microcephaly in the years 2015 and 2016. The investigation of the cases raised the suspicion of the association of these cases with maternal infections by the zika virus. Also, in 2015, there was an epidemic of zika virus infection in Brazil, reinforcing this hypothesis. Objective: The objective of this study was to identify factors associated with the diagnosis of microcephaly in newborns, including zika virus infection. Methods: We conducted a case-control study. The cases were defined as children who received clinical and imaging diagnosis of microcephaly, born after October 2015 in Ceará, Brazil, which recorded the highest number of microcephaly cases in Brazil during the outbreak. The cases were identified in medical records of public and private maternity hospitals and in child development stimulation clinics tracked until June 2017. Epidemiological, clinical, and socioeconomic variables were collected, visiting their homes and confirming data from their medical records. Controls were children without microcephaly identified in the vicinity of the residence of each case. Logistic regression models were used to control confounding. Findings: We evaluated 58 cases and 116 controls. The odds of having a baby with microcephaly was 14 times higher among mothers who had zika virus infection (p < 0.001), after multivariate analysis. Arboviruses infections symptoms, as fever (p = 0.220), skin change (p < 0.001), and joint pain (p = 0.002) also demonstrated an association with microcephaly. Conclusions: Maternal infection zika virus was associated with a diagnosis of microcephaly. Our study contributes to the investigation of the epidemiological factors associated with the diagnosis of microcephaly.pt_BR
dc.language.isoenpt_BR
dc.publisherAnnals of Global Healthpt_BR
dc.subjectInfecção por Zika viruspt_BR
dc.subjectZika Virus Infectionpt_BR
dc.subjectMicrocefaliapt_BR
dc.subjectMicrocephalypt_BR
dc.titleZika virus infection and microcephaly: a case-control study in Brazilpt_BR
dc.typeArtigo de Periódicopt_BR
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