Análise de Biomarcadores Inflamatórios fecais em crianças na Primeira Infância submetidas a Estresse Tóxico.

Abstract

Toxic stress (ACE) can occur when your child experiences severe, frequent and / or prolonged adversity - such as physical or emotional abuse, chronic neglect, caregiver substance abuse or mental illness, exposure the violence and / or the accumulated burden of the family's economic difficulties - without adequate adult support. This type of prolonged activation of stress response systems can disrupt the development of brain architecture and other organ systems and increase the risk of stress-related illnesses and cognitive impairment to adulthood, as well as many other physical illnesses. It is worth noting that these children often have diseases related to gastrointestinal tract problems. These inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn's disease, are chronic inflammatory disorders of the gastrointestinal tract that are often diagnosed in adolescence and young adulthood, with an increasing incidence in pediatric situations. Serological and fecal markers, already present in clinical practice, can provide quantitative and reproducible tools that complement clinical assessment to assist in the diagnosis and management of IBD. Fecal biomarkers have been studied for their ability to identify patients with IBD, monitor disease activity and predict recurrence. Thus, the discovery of these new biomarkers and their use in combination with those currently available in clinical practice could significantly improve the assessment of patients with IBD, as well as their discovery at an early age may assist in the development of prevention strategies. In this context, the present study aimed to analyze inflammatory bowel parameters such as myeloperoxidase (MPO) and nitrite activity through spectrophotometric techniques in the feces of children submitted to 0-2 ACES and more than 4 ACES attended at the Institute of Early Childhood (IPREDE) located in the municipality of Fortaleza-CE. For the study 11 children were recruited, 4 of them submitted to 0-2 ACES and 7 submitted to more than 4 ACES. No significant differences were observed between the levels of these oxidative-inflammatory process markers. An important limitation of the present study was the small sample size mainly in the 0-2 ACES group. Therefore, although the present study did not observe significant differences in nitrite and MPO levels in the feces of children exposed to 0-2 or more than 4 ACES, further studies with larger numbers of patients should be designed.