Carcinoma hepatocelular na cirrose criptogênica: experiência de um centro

Abstract

Objectives: To evaluate the clinical characteristics of patients transplanted by Hepatocellular carcinoma (HCC) by Cryptogenic cirrhosis and Hepatitis C virus. Method: A total of 45 patients were retrospectively analyzed between 2003 and 2015. Of these, 19 were patients who transplanted under the undetermined etiology of cirrhosis and CHC and 26 with Hepatitis C virus (HCV) + CHC infection. Four patients were excluded because another etiology for cirrhosis after histopathology of the explant was discovered, using a chi-square test for analysis. Results: Ten variables were analyzed between groups, including bilirubin (P<0.035), albumin (P<0.03), the number of nodes (P<0.026), Child-Pugh rating (P<0.003) and INR (P<0.035), and there were significant differences among the groups that were more abnormal in patients with cryptogenic cirrhosis. Approximately 21% of patients with cryptogenic cirrhosis showed evidence of other pathologies. Conclusion: Many heteroatons non-alcoholic hepatitis and non-alcoholic fatty liver disease are considered cryptogenic, with the length of stay in the queue being greater than the HCV patients; Transplantation for CHC due to cryptogenic cirrhosis is accompanied by worse laboratory results and a greater number of nodules involved when compared with those due to HCV.