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Title in Portuguese: Levothyroxine Replacement Improves Oxidative Status in Primary Hypothyroidism
Author: Masullo, Laís Farias
Magalhães, Rejane Araújo
Lemes, Romélia Pinheiro Gonçalves
Almeida Filho, Tarcísio Paulo de
Castro, Marilena Facundo de
Maia Filho, Pedro Aurio
Cunha, Tainá Osterno Vasconcelos
Quidute, Ana Rosa Pinto
Fontenele, Eveline Gadelha Pereira
Sun, Guang
Martins, Manoel Ricardo Alves
Keywords: Estresse Oxidativo
Oxidative Stress
Reactive Oxygen Species
Espécies Reativas de Oxigênio
Issue Date: Nov-2018
Publisher: Frontiers in Endocrinology
Citation: MASULLO, Laís Farias et al. Levothyroxine replacement improves oxidative status in primary hypothyroidism. Frontiers in Endocrinology, v. 9, p. 1-5, nov. 2018.
Abstract: Objective: Although hypothyroidism has been linked to oxidative stress, data regarding the relationship between thyroid hormone levels and oxidative stress is still inconsistent. This study was designed to evaluate the effect of levothyroxine replacement on oxidative stress in women with primary hypothyroidism. Design: A total of 25 female patients with primary hypothyroidism were included. Oxidative stress markers were measured before and after levothyroxine replacement treatment in all patients. Methods: Oxidative stress was evaluated through the measurement of oxidants (thiobarbituric acid reactive substances [TBARS] and nitrite/nitrate levels), and antioxidants (superoxide dismutase and catalase activity). Results: Antioxidant catalase activity (63.77 ± 23.8 vs. 50.12 ±12.75 atv/min; p = 0.03) was significantly increased and the levels of TBARS (3.02 ± 0.86 vs. 3.55 ± 0.87μM; p = 0.03) were significantly decreased in the state of euthyroidism after levothyroxine replacement compared to the hypothyroidism before levothyroxine treatment. No significant change in neither nitrite/nitrate concentration (p = 0.18) nor in superoxide dismutase activity (p = 0.93) after L-T4 adjustment was found. Conclusions: Our data demonstrate that levothyroxine replacement improved oxidative status in patients with primary hypothyroidism, indexed by the significantly decreased levels of malonaldehyde (MDA) and increased catalase (CAT) activity.
metadata.dc.type: Artigo de Periódico
ISSN: 1664-2392
Appears in Collections:DFAR - Artigos publicados em revistas científicas

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