Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/36061
Title in Portuguese: Synthesis of selenium-quinone hybrid compounds with potential antitumor activity via Rh-Catalyzed C-H bond activation and click reactions
Author: Jardim, Guilherme A. M.
Cruz, Eduardo H. G. da
Valença, Wagner O.
Lima, Daisy J. B.
Cavalcanti, Bruno C.
Pessoa, Claudia
Rafique, Jamal
Braga, Antonio L.
Jacob, Claus
Silva Júnior, Eufrânio N. da
Keywords: Selênio
Selenium
Issue Date: 2018
Publisher: Molecule
Citation: JARDIM, G. A. M. et al. Synthesis of selenium-quinone hybrid compounds with potential antitumor activity via Rh-Catalyzed C-H bond activation and click reactions. Molecules, Basel, v. 23, n. 83, p. 1-16, 2018.
Abstract: Abstract: In continuation of our quest for new redox-modulating catalytic antitumor molecules, selenium-containing quinone-based 1,2,3-triazoles were synthesized using rhodium-catalyzed C-H bond activation and click reactions. All compounds were evaluated against five types of cancer cell lines: HL-60 (human promyelocytic leukemia cells), HCT-116 (human colon carcinoma cells), SF295 (human glioblastoma cells), NCIH-460 (human lung cells) and PC3 (human prostate cancer cells). Some compounds showed good activity with IC50 values below 1 M. The cytotoxic potential of the naphthoquinoidal derivatives was also evaluated in non-tumor cells, exemplified by L929 cells. Overall, these compounds represent promising new lead derivatives and stand for a new class of chalcogenium-containing derivatives with potential antitumor activity.
URI: http://www.repositorio.ufc.br/handle/riufc/36061
metadata.dc.type: Artigo de Periódico
ISSN: 1420-3049, ESSN: 1420-3049)
Appears in Collections:PPGF - Artigos publicados em revistas científica

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