O uso adjuvante de antibióticos sistêmicos no tratamento da periodontite agressiva: uma revisão sistemática

Abstract

The aim of this systematic review is to evaluate the success or failure rates of antibiotic use as an adjuvant factor in the treatment of Aggressive Periodontitis (AgP) with non-surgical periodontal therapy. Materials and methods: An advanced search was performed in the PubMed database, without stipulation of study data for research and that included articles published up to April 2018 and in the English language. In the articles found, the following inclusion criteria were applied: studies that are classified as Randomized Clinical Trials (RCT), double or triple-blind, presenting a control group with placebo, with a minimum follow-up of six months and that included generalized AgP, located or both. Results: 320 articles were found during electronic research, 37 were read in their entirety as potential studies and 9 were included. The studies had different characteristics in relation to the number of participants, antibiotics employed, dosages and treatment period, as well analysis of variable clinical parameters, including microbiological and immunological evaluations. Amoxicillin associated with metronidazole and the moxifloxacin have been shown in most studies to be an additional benefit in the treatment of AgP. The anti-infective therapy presented results comparable to the use of these drugs. Conclusion: The combination amoxicillin and metronidazole was the most widely investigated and demonstrated additional benefits in most studies, as well as moxifloxacin, not forgetting also the positive results of anti-infective therapy. However, news RCT should be elaborated with the intention of establishing guidelines, including drugs of choice, dosage and prescription period, for a treatment of AgP with greater accuracy and safety.