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dc.contributor.authorDodou, H.V.-
dc.contributor.authorBatista, A. H. de Morais-
dc.contributor.authorSales, G.W.P.-
dc.contributor.authorMedeiros, S. C. de-
dc.contributor.authorRodrigues, M. L.-
dc.contributor.authorNogueira, P.C.N.-
dc.contributor.authorSilveira, E.R.-
dc.contributor.authorNogueira, N. A. P.-
dc.date.accessioned2017-10-10T17:54:18Z-
dc.date.available2017-10-10T17:54:18Z-
dc.date.issued2017-
dc.identifier.citationDODOU, H. V. et al. Violacein antimicrobial activity on Staphylococcus epidermidis and synergistic effect on commercially available antibiotics. Journal of applied microbiology, Oxford, v. 123, p. 853-860, 2017.pt_BR
dc.identifier.issn1364- 5072-
dc.identifier.urihttp://www.repositorio.ufc.br/handle/riufc/26557-
dc.description.abstractAims: The study aimed to assess whether violacein has antimicrobial activity on Staphylococcus epidermidis and synergistically modulates the action of commercially available antimicrobial drugs. Methods and Results: Violacein showed excellent antimicrobial activity on biofilm-forming and nonbiofilm-forming S. epidermidis strains (ATCC 35984) (ATCC 12228), with bacteriostatic (MIC = 20 lg ml 1 and 10 lg ml 1 respectively) and bactericidal effects (MBC = 20 lg ml 1 for both strains), observed in short periods of exposure. The violacein bactericidal concentration led to S. epidermidis death after 2–3 h of exposure. Additionally, violacein synergistically modulated the activity of different antimicrobial classes on S. epidermidis ATCC 12228 (81 8%; n = 9) and on S. epidermidis ATCC 35984 (54 5%; n = 6), reducing the MIC of these antibiotics by up to 16-fold. Conclusion: Violacein shows excellent antimicrobial activity on S. epidermidis strains. Significance and Impact of the Study: Violacein shows the potential for the development of a new drug for the treatment of infections caused by S. epidermidis.pt_BR
dc.language.isoenpt_BR
dc.publisherJournal of applied microbiologypt_BR
dc.subjectStaphylococcus epidermidispt_BR
dc.subjectAntibacterianospt_BR
dc.subjectAnti-Bacterial Agentspt_BR
dc.titleViolacein antimicrobial activity on Staphylococcus epidermidis and synergistic effect on commercially available antibioticspt_BR
dc.typeArtigo de Periódicopt_BR
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