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dc.contributor.authorRoomruangwong, Chutima-
dc.contributor.authorBarbosa, Decio Sabbatini-
dc.contributor.authorMatsumoto, Andressa Keiko-
dc.contributor.authorNogueira, André de Souza-
dc.contributor.authorKanchanatawan, Buranee-
dc.contributor.authorSirivichayakul, Sunee-
dc.contributor.authorCarvalho, André Ferrer-
dc.contributor.authorDuleu, Sebastien-
dc.contributor.authorGeffard, Michel-
dc.contributor.authorMoreira, Estefania Gastaldello-
dc.contributor.authorMaes, Michael-
dc.date.accessioned2017-08-28T12:34:40Z-
dc.date.available2017-08-28T12:34:40Z-
dc.date.issued2017-12-
dc.identifier.citationROOMRUANGWONG, CHUTIMA et al. Activated neuro-oxidative and neuro-nitrosative pathways at the end of term are associated with inflammation and physio-somatic and depression symptoms, while predicting outcome characteristics in mother and baby. Journal of Affective Disorders, v. xx, p. 49-58, dez. 2017.pt_BR
dc.identifier.issn0165-0327-
dc.identifier.urihttp://www.repositorio.ufc.br/handle/riufc/25133-
dc.language.isoenpt_BR
dc.publisherJournal of Affective Disorderspt_BR
dc.subjectDepressionpt_BR
dc.subjectInflammationpt_BR
dc.subjectComplexo Antígeno-Anticorpo (Immune)pt_BR
dc.titleActivated neuro-oxidative and neuro-nitrosative pathways at the end of term are associated with inflammation and physio-somatic and depression symptoms, while predicting outcome characteristics in mother and babypt_BR
dc.typeArtigo de Periódicopt_BR
dc.description.abstract-ptbrObjectives: To examine oxidative & nitrosative stress (O & NS) biomarkers at the end of term in relation to perinatal affective symptoms, neuro-immune biomarkers and pregnancy-related outcome variables. Methods: We measured plasma advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), total radical trapping antioxidant parameter (TRAP), -sulfhydryl (-SH), peroxides (LOOH) and paraoxonase (PON)1 activity in pregnant women with and without prenatal depression and non-pregnant controls. Results: Pregnancy is accompanied by significantly increased AOPP and NOx, and lowered TRAP, -SH and LOOH. Increased O & NS and lowered LOOH and -SH levels are associated with prenatal depressive and physiosomatic symptoms (fatigue, pain, dyspepsia, gastro-intestinal symptoms). Increased AOPP and NOx are significantly associated with lowered –SH, TRAP and zinc, and with increased haptoglobin and C-reactive protein levels. Increased O & NS and lowered TRAP and PON 1 activity, at the end of term predict mother (e.g. hyperpigmentation, labor duration, caesarian section, cord length, breast milk flow) and baby (e.g. sleep and feeding problems) outcome characteristics. Conclusions: Pregnancy is accompanied by interrelated signs of O & NS, lowered antioxidant defenses and activated neuro-immune pathways. Increased O & NS at the end of term is associated with perinatal depressive and physio-somatic symptoms and may predict obstetric and behavioral complications in mother and baby.pt_BR
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