Perfil hematológico e bioquímico de pacientes com doença de Chagas atendidos por um serviço de atenção farmacêutica no estado do Ceará

Abstract

Introduction: Chagas’ disease (DC) is a parasite caused by the infectious agent Trypanosoma cruzi. In Brazil, the specific treatment of CD is performed with Benzonidazole (Bz), which due to its toxicity, can lead to the appearance of several adverse reactions to patients who use it. Therefore, there is a certain concern in evaluating the patient before starting the use of Bz, in order to verify possible hematological and biochemical alterations that may be attributed to the use of benzonidazole. Objective: to delineate the profile of the hematological and biochemical parameters of patients with CD before the pharmacotherapy with Bz. Methodology: Retrospective study of sociodemographic and laboratory parameters (erythrogram, leukogram, platelets, aspartate aminotransferase- TGO, alanine aminotransferase - TGP, urea and creatinine) from 89 chronic Chagas’ patients treated at the Pharmaceutical Care Service of Federal University of Ceará, the January 2010 to December 2015. Results: The population studied was female (52.8%), mean age 53.6 years, low income and education, retired majority, from the interior of the state of Ceará. As far as hematological and biochemical analysis are concerned, it is observed that all parameters are within the reference values. In the comparison between genders, statistical analysis between means showed a significant difference in erythrocytes, hematocrit, hemoglobin, platelets and lymphocyte counts. Conclusion: Despite the evidence of a profile within the normal reference values, the follow-up of these laboratory parameters is of paramount importance in the follow-up of the chagasic patient, since adverse reactions may appear well at the beginning of Benzonidazole treatment, often leading to medication interruption.