Please use this identifier to cite or link to this item:
Title in Portuguese: Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazi
Author: Silva-Pinto, Ana Cristina
Ladeira, Simery de Oliveira Domingues
Brunetta, Denise Menezes
Santis, Gil Cunha De
Angulo, Ivan de Lucena
Covas, Dimas Tadeu
Keywords: Anemia Falciforme
Anemia, Sickle Cell
Issue Date: Sep-2014
Publisher: Revista Brasileira de Hematologia e Hemoterapia
Citation: SILVA-PINTO, A. C. et al. Sickle cell disease and pregnancy : analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazil. Revista Brasileira de Hematologia e Hemoterapia, São Paulo, v. 36, n. 5, p. 329-333, 2014.
Abstract: Objective: The objective of this study was to verify the evolution of pregnancies in sickle cell patients followed at one institution over a period of 12 years (January 2000 to June 2012). Methods: The study evaluated 34 pregnant women with sickle cell disease with a mean age of 23.9 ± 5.3 years. The incidence of obstetric complications, non-obstetric complications linked to sickle cell disease and complications in the newborn were analyzed. Results: A total of 26% of the cases reported previous miscarriages, 20% had preterm labor, 10% had pre-eclampsia, and 5% had gestational diabetes. Forty-one percent of the deliveries were cesarean sections and 29% of patients required blood transfusions. In respect to sickle cell disease, 62% of patients had vaso-occlusive crises, 29% had acute chest syndrome, 23% had urinary tract infection, 15% had impaired cardiac function and 6% developed pulmonary hypertension. Only one patient died in the postnatal period due to acute chest syndrome. The mean gestational age was 37.8 ± 2.63 weeks, and mean newborn weight was 2.809 ± 643.8 g. There were seven fetal losses, including three stillbirths and four miscarriages. The impact of transfusion therapy on the incidence of maternal–fetal complications during pregnancy was evaluated. Conclusions: Pregnancy in sickle cell patients is still associated with complications. Although no statistical difference was observed between transfused and non-transfused women, there were no deaths (fetal or maternal) in transfused patients whereas one maternal death and three stillbirths occurred in non-transfused women. A larger study of sickle cell pregnant women will be necessary to elucidate the actual role of transfusion during pregnancy in sickle cell disease.
metadata.dc.type: Artigo de Periódico
ISSN: 1516-8484
Appears in Collections:DCIR - Artigos publicados em revista científica

Files in This Item:
File Description SizeFormat 
2014_art_acsilva-pinto.pdf426,27 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.